ORBIMED ADVISORS LLC

CIK 0001055951 · Q2 2026

13F Equity AUM

$5.4B

+7.0% QoQ

Positions

123

-110 QoQ

AUM Rank

#1,458

Top 12%

Skill Alpha (FF)

+0.1%/yr^ns

No Clear Edge

Rank #2,249 · Top 27%

vs S&P -4.6%/yr (unadj.)

Quarters Tracked

~13 years

Portfolio Concentration

Top 5: 30.7%Top 10: 42.1%Top 20: 57.1%

EWTX11.7%

ELVN6.4%

LLY5.7%

MBX3.5%

SVA3.4%

AZN3.2%

GPCR2.2%

SION2.1%

CRVS2.0%

AVBP1.9%

Others (113)57.9%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

No sector data available.

Position Sizing

Positions: 123Median: 0.44%Avg: 0.81%

0–0.5%

72(14.6%)

0.5–1%

21(16.4%)

1–3%

24(35.1%)

3–5%

3(10.1%)

5%+

3(23.8%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 123vs 20 funds

0%Low

123

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New0Increased0Decreased0Exited0

No position changes this quarter.

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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