ORBIMED ADVISORS LLC

CIK 0001055951 · Q2 2026

13F Equity AUM

$5.4B

+7.0% QoQ

Positions

123

+13 QoQ

AUM Rank

#803

Top 9%

Skill Alpha (FF)

+0.5%/yr^ns

No Clear Edge

Rank #2,286 · Top 28%

vs S&P -4.9%/yr (unadj.)

Quarters Tracked

~13 years

Portfolio Concentration

Top 5: 30.7%Top 10: 42.1%Top 20: 57.1%

EWTX11.7%

ELVN6.4%

LLY5.7%

MBX3.5%

SVA3.4%

AZN3.2%

GPCR2.2%

SION2.1%

CRVS2.0%

AVBP1.9%

Others (113)57.9%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare95.5%

Unclassified3.7%

Other0.9%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 123Median: 0.44%Avg: 0.81%

0–0.5%

72(14.6%)

0.5–1%

21(16.4%)

1–3%

24(35.1%)

3–5%

3(10.1%)

5%+

3(23.8%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 123vs 20 funds

0%Low

123

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New37Increased34Decreased26Exited24

New Positions

UNH1.3%

+171K

ASCENDIS PHARMA A/S1.2%

+244K

HUM1.2%

+164K

ODYSSEY THERAPEUTICS…1.0%

+3.0M

ARQT1.0%

+2.0M

XBI0.9%

+300K

WST0.5%

+71K

AURA0.4%

+3.3M

SYRE0.3%

+186K

WAT0.3%

+40K

Increased

YB4P0.5%

+3.3M(+524%)

PRLD1.4%

+2.8M(+26%)

QTTB1.0%

+1.9M(+83%)

COGT1.2%

+1.4M(+422%)

GPCR2.2%

+734K(+50%)

TRAW0.0%

+598K(+99%)

SNDX0.6%

+580K(+60%)

IMA0.1%

+531K(+140%)

ATAI0.1%

+451K(+130%)

LFST0.2%

+447K(+89%)

Decreased

ELVN6.4%

-1,182,906(-15%)

RLMD0.5%

-1,084,669(-23%)

TRVI0.5%

-1,024,107(-42%)

SION2.1%

-974,825(-28%)

BSX1.2%

-898,900(-38%)

IRON0.5%

-710,015(-67%)

ORIC0.4%

-678,929(-25%)

NPCE0.4%

-591,402(-28%)

HELP0.4%

-561,443(-15%)

PRELUDE THERAPEUTICS…0.6%

-530,713(-9%)

Exited

-124,306,000

-82,010,995

-125,000,000

-1,946,500

-265,800

-181,977

-10,570,300

-497,800

-791,000

-39,900

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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