ARCH Venture Management, LLC

CIK 0001274403 · Q2 2026

13F Equity AUM

$1.1B

+62.5% QoQ

Positions

+2 QoQ

AUM Rank

#3,216

Top 26%

Skill Alpha (FF)

+26.8%/yr^ns

No Clear Edge

Rank #94 · Top 1%

vs S&P -15.9%/yr (unadj.)

Quarters Tracked

~6 years

Portfolio Concentration

Top 5: 68.5%Top 10: 99.3%Top 20: 100.0%

PARABILIS MEDICINES INC15.9%

BEAM14.2%

RAPP14.1%

SEAPORT THERAPEUTICS INC12.4%

ERAS11.8%

VIR11.8%

MAZE11.2%

LYEL4.1%

GENERATE BIOMEDICINES INC3.0%

TXG0.8%

Others (2)0.7%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare68.7%

Unclassified31.4%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 12Median: 11.47%Avg: 8.33%

0–0.5%

1(0.1%)

0.5–1%

2(1.4%)

1–3%

1(3.0%)

3–5%

1(4.1%)

5%+

7(91.4%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 12vs 20 funds

0%Low

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New3Increased0Decreased1Exited1

New Positions

PARABILIS MEDICINES …15.9%

+6.4M

SEAPORT THERAPEUTICS…12.4%

+6.3M

BOLD0.6%

+2.7M

Decreased

VIR11.8%

-222,500(-2%)

Exited

QTTB

-320,482

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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