GREAT POINT PARTNERS LLC

CIK 0001281446 · Q2 2026

13F Equity AUM

$529.1M

+21.6% QoQ

Positions

-1 QoQ

AUM Rank

#4,772

Top 38%

Skill Alpha (FF)

+12.8%/yr^ns

No Clear Edge

Rank #278 · Top 3%

vs S&P -1.1%/yr (unadj.)

Quarters Tracked

~13 years

Portfolio Concentration

Top 5: 35.7%Top 10: 55.4%Top 20: 81.4%

ABVX15.2%

VOR5.9%

IBRX5.0%

VERA4.9%

ZURA4.7%

ALMS4.5%

SLGL3.8%

RARE3.8%

DFTX3.8%

ANNX3.8%

Others (31)44.6%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare97.2%

Unclassified2.8%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 41Median: 1.53%Avg: 2.44%

0–0.5%

3(1.0%)

0.5–1%

10(7.7%)

1–3%

16(29.5%)

3–5%

10(40.7%)

5%+

2(21.1%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 41vs 20 funds

0%Low

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New12Increased7Decreased9Exited13

New Positions

ABVX15.2%

+604K

RARE3.8%

+600K

DFTX3.8%

+425K

SGMT3.0%

+2.0M

IFRX1.3%

+3.0M

JATT II ACQUISITION …1.1%

+500K

ALT1.0%

+1.7M

AMANAT ACQUISITION C…1.0%

+500K

SCYNEXIS INC0.7%

+944K

ELVN0.7%

+70K

Increased

IRD1.5%

+1.6M(+507%)

ANNX3.8%

+1.0M(+40%)

IMMX2.5%

+928K(+265%)

VERA4.9%

+401K(+201%)

MLTX3.1%

+356K(+71%)

CTNM2.9%

+121K(+15%)

LBRX1.9%

+17K(+6%)

Decreased

PALI0.9%

-1,120,938(-33%)

AMLX2.4%

-1,050,000(-60%)

SLN0.9%

-570,489(-56%)

CLYM2.5%

-334,130(-25%)

PMN0.2%

-285,252(-77%)

NGNE2.1%

-147,820(-30%)

NKTR2.3%

-141,453(-45%)

DRUG1.4%

-110,397(-50%)

VOR5.9%

-50,000(-3%)

Exited

-374,000

-675,000

-545,625

-964,462

-524,066

-1,350,000

-7,554,347

-2,238,496

-327,307

-796,558

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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