GREAT POINT PARTNERS LLC

CIK 0001281446 · Q1 2026

13F Equity AUM

$435.1M

+41.1% QoQ

Positions

+13 QoQ

AUM Rank

#4,713

Top 38%

Skill Alpha (FF)

+11.8%/yr^ns

No Clear Edge

Rank #225 · Top 3%

vs S&P -3.4%/yr (unadj.)

Quarters Tracked

~12 years

Portfolio Concentration

Top 5: 31.1%Top 10: 52.5%Top 20: 77.2%

APGE7.2%

VOR7.2%

ZURA5.8%

AMLX5.6%

IBRX5.3%

NKTR5.2%

SLGL5.0%

ALMS4.3%

DRUG3.7%

ANNX3.2%

Others (32)47.5%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare100.0%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 42Median: 1.78%Avg: 2.38%

0–0.5%

4(1.5%)

0.5–1%

6(4.0%)

1–3%

19(32.7%)

3–5%

7(25.6%)

5%+

6(36.3%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 38Unique: 4vs 20 funds

0.5%Low

Fund positions

7,299

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

Most Similar Funds

Top 9 benchmark funds with highest portfolio overlap (Jaccard similarity)

GEODE CAPITAL MANAGEMENT, LLC

1.1%

VANGUARD CAPITAL MANAGEMENT LLC

MORGAN STANLEY

0.6%

BlackRock, Inc.

0.8%

STATE STREET CORP

0.8%

BANK OF AMERICA CORP /DE/

0.5%

VANGUARD PORTFOLIO MANAGEMENT LLC

0.8%

FMR LLC

0.8%

JPMORGAN CHASE & CO

0.4%

Jaccard similarity per fund: shared CUSIPs / (fund A + fund B − shared). Higher values indicate more similar portfolios.

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Position Changes This Quarter

New21Increased8Decreased4Exited8

New Positions

IBRX5.3%

+3.0M

SLGL5.0%

+274K

ALMS4.3%

+856K

DRUG3.7%

+220K

ANNX3.2%

+2.5M

ZBIO2.4%

+524K

MLTX2.1%

+500K

VERA1.8%

+199K

LBRX1.7%

+300K

CMPX1.6%

+1.4M

Increased

ZURA5.8%

+400K(+10%)

VOR7.2%

+380K(+28%)

CLYM2.1%

+355K(+36%)

SLN1.2%

+212K(+26%)

JBIO3.1%

+158K(+20%)

NGNE2.3%

+150K(+43%)

NKTR5.2%

+106K(+50%)

CTNM2.4%

+198(+0%)

Decreased

CNTX1.4%

-2,445,215(-52%)

CGEM1.0%

-334,032(-53%)

IMVT3.1%

-204,375(-27%)

KALV3.1%

-10,632(-2%)

Exited

-250,000

-581,187

-400,000

-350,000

-800,000

-300,000

-300,000

-700,000

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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