Casdin Capital, LLC

CIK 0001534261 · Q2 2026

13F Equity AUM

$2.0B

+51.3% QoQ

Positions

+3 QoQ

AUM Rank

#1,540

Top 18%

Skill Alpha (FF)

-3.2%/yr^ns

No Clear Edge

Rank #7,011 · Top 84%

vs S&P -11.3%/yr (unadj.)

Quarters Tracked

~10 years

Portfolio Concentration

Top 5: 63.2%Top 10: 77.4%Top 20: 91.7%

RVMD24.2%

RLAY15.0%

WGS12.7%

BLFS6.6%

ILMN4.7%

FLB3.7%

GPCR3.2%

DNLI2.6%

NGNE2.4%

BEAM2.3%

Others (33)22.6%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare98.0%

Other1.9%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 43Median: 0.88%Avg: 2.33%

0–0.5%

15(2.4%)

0.5–1%

8(5.9%)

1–3%

13(21.7%)

3–5%

3(11.5%)

5%+

4(58.5%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 43vs 20 funds

0%Low

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New6Increased9Decreased3Exited3

New Positions

SION0.9%

+400K

PARABILIS MEDICINES …0.9%

+646K

SRPT0.4%

+470K

QURE0.3%

+150K

EDIT0.1%

+445K

KARDIGAN INC0.1%

+50K

Increased

RLAY15.0%

+1.6M(+11%)

PSNL1.7%

+950K(+59%)

ANL0.7%

+712K(+132%)

WGS12.7%

+700K(+23%)

SRRK1.8%

+315K(+90%)

GRAL1.6%

+250K(+109%)

DNLI2.6%

+205K(+11%)

NGNE2.4%

+125K(+9%)

MAZE1.3%

+85K(+11%)

Decreased

BLFS6.6%

-1,302,165(-22%)

TXG2.0%

-1,225,000(-54%)

GH1.4%

-130,000(-41%)

Exited

QIAGEN NV

-360,000

TEM

-294,127

MLTX

-450,000

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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