Opaleye Management Inc.

CIK 0001595855 · Q2 2026

13F Equity AUM

$1.1B

+45.4% QoQ

Positions

-54 QoQ

AUM Rank

#3,204

Top 26%

Skill Alpha (FF)

+5.8%/yr^ns

No Clear Edge

Rank #557 · Top 7%

vs S&P -5.7%/yr (unadj.)

Quarters Tracked

~12 years

Portfolio Concentration

Top 5: 46.7%Top 10: 64.8%Top 20: 82.4%

LQDA17.7%

ETON9.4%

HROW9.2%

IRON5.7%

URGN4.8%

APGE4.7%

MGTX4.3%

SLGL3.4%

RZLT3.0%

TGTX2.7%

Others (48)35.2%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

No sector data available.

Position Sizing

Positions: 58Median: 0.62%Avg: 1.72%

0–0.5%

25(5.6%)

0.5–1%

6(3.8%)

1–3%

19(31.5%)

3–5%

4(17.2%)

5%+

4(41.9%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 58vs 20 funds

0%Low

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New0Increased0Decreased0Exited0

No position changes this quarter.

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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