5AM Venture Management, LLC

CIK 0001799883 · Q2 2026

13F Equity AUM

$287.9M

-20.1% QoQ

Positions

-4 QoQ

AUM Rank

#5,160

Top 59%

Skill Alpha (FF)

-12.3%/yr^ns

No Clear Edge

Rank #8,137 · Top 98%

vs S&P -31.4%/yr (unadj.)

Quarters Tracked

~6 years

Portfolio Concentration

Top 5: 52.1%Top 10: 85.6%Top 20: 100.0%

MPLT11.8%

TYRA11.4%

TRDA10.4%

PHVS9.6%

CAMP8.9%

ARTV7.9%

TECX7.2%

ZNTL6.7%

TCE26.4%

EYPT5.2%

Others (6)14.4%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare100.0%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 16Median: 6.54%Avg: 6.25%

0–0.5%

0(0.0%)

0.5–1%

0(0.0%)

1–3%

5(10.6%)

3–5%

1(3.8%)

5%+

10(85.6%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 16vs 20 funds

0%Low

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New0Increased0Decreased1Exited4

Decreased

SRZN2.4%

-116,250(-30%)

Exited

-3,485,971

-580,945

-572,665

-291,788

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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