Paradigm Biocapital Advisors LP

CIK 0001855655 · Q2 2026

13F Equity AUM

$5.3B

+9.1% QoQ

Positions

-7 QoQ

AUM Rank

#810

Top 9%

Skill Alpha (FF)

+5.4%/yr^ns

No Clear Edge

Rank #693 · Top 8%

vs S&P +4.3%/yr (unadj.)

Quarters Tracked

~4 years

Portfolio Concentration

Top 5: 56.9%Top 10: 75.2%Top 20: 96.2%

RVMD22.3%

NUVL13.7%

EWTX7.8%

GMAB6.8%

SYRE6.4%

APGE3.9%

ORKA3.8%

TNGX3.7%

BLTE3.5%

ERAS3.3%

Others (18)24.8%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare99.6%

Other0.4%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 28Median: 2.45%Avg: 3.57%

0–0.5%

5(1.9%)

0.5–1%

4(2.8%)

1–3%

8(16.9%)

3–5%

6(21.6%)

5%+

5(56.9%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 0Unique: 28vs 20 funds

0%Low

Fund positions

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

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Position Changes This Quarter

New7Increased12Decreased7Exited14

New Positions

ALNY2.7%

+480K

MBX2.6%

+2.5M

JBIO1.2%

+2.9M

SP4P0.6%

+5.0M

MPLT0.5%

+686K

KARDIGAN INC0.4%

+900K

EDIT0.3%

+5.6M

Increased

GMAB6.8%

+5.2M(+65%)

VRDN2.3%

+3.6M(+114%)

EWTX7.8%

+2.9M(+39%)

TNGX3.7%

+2.3M(+59%)

SYRE6.4%

+1.9M(+96%)

ASMB0.8%

+888K(+134%)

OLMA2.0%

+650K(+8%)

NUVL13.7%

+600K(+11%)

APGE3.9%

+228K(+17%)

TARS3.3%

+213K(+8%)

Decreased

PCVX2.3%

-2,665,168(-56%)

LXEO0.4%

-2,008,752(-32%)

ERAS3.3%

-842,702(-8%)

RVMD22.3%

-294,380(-4%)

EYPT0.8%

-252,040(-8%)

TYRA1.1%

-226,384(-11%)

ORKA3.8%

-175,790(-8%)

Exited

-5,774,016

-3,574,048

-2,216,499

-1,480,857

-772,473

-2,744,399

-1,226,080

-625,000

VERADERMICS INC

-525,000

URGN

-1,703,949

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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