Paradigm Biocapital Advisors LP

CIK 0001855655 · Q1 2026

13F Equity AUM

$4.9B

+24.9% QoQ

Positions

+5 QoQ

AUM Rank

#1,029

Top 8%

Skill Alpha (FF)

+6.1%/yr^ns

No Clear Edge

Rank #529 · Top 6%

vs S&P -3.4%/yr (unadj.)

Quarters Tracked

~4 years

Portfolio Concentration

Top 5: 48.4%Top 10: 67.7%Top 20: 89.2%

ACLX13.6%

RVMD13.2%

NUVL11.2%

PCVX5.7%

EWTX4.7%

GMAB4.4%

IM8N4.2%

TARS3.7%

BLTE3.6%

ERAS3.4%

Others (25)32.3%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare99.3%

Other0.7%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 35Median: 1.76%Avg: 2.86%

0–0.5%

5(1.5%)

0.5–1%

6(4.0%)

1–3%

14(26.8%)

3–5%

6(24.0%)

5%+

4(43.6%)

Count of positions per weight bucket — (%) = combined portfolio weight

Loading summary cards...

Portfolio Overlap

Shared: 34Unique: 1vs 20 funds

0.5%Low

Fund positions

7,299

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

Most Similar Funds

Top 9 benchmark funds with highest portfolio overlap (Jaccard similarity)

MORGAN STANLEY

0.6%

GEODE CAPITAL MANAGEMENT, LLC

BlackRock, Inc.

0.8%

STATE STREET CORP

0.9%

FMR LLC

BANK OF AMERICA CORP /DE/

0.6%

VANGUARD CAPITAL MANAGEMENT LLC

0.8%

JPMORGAN CHASE & CO

0.6%

VANGUARD PORTFOLIO MANAGEMENT LLC

0.9%

Jaccard similarity per fund: shared CUSIPs / (fund A + fund B − shared). Higher values indicate more similar portfolios.

Loading overlap analysis...

Position Changes This Quarter

New10Increased13Decreased7Exited5

New Positions

IM8N4.2%

+1.3M

BLTE3.6%

+1.1M

CNTA2.9%

+3.6M

CYTK2.0%

+1.5M

TNGX1.7%

+4.0M

MAZE1.7%

+2.7M

TYRA1.6%

+2.1M

MIRM1.2%

+625K

VERADERMICS INC0.7%

+525K

GPCR0.5%

+545K

Increased

VRDN1.3%

+1.7M(+118%)

LXEO0.7%

+1.4M(+30%)

TERN2.4%

+1.4M(+174%)

GMAB4.4%

+928K(+13%)

EWTX4.7%

+824K(+13%)

PCVX5.7%

+725K(+18%)

ORKA2.3%

+610K(+36%)

SYRE2.0%

+490K(+33%)

OLMA2.4%

+476K(+6%)

APGE2.3%

+225K(+20%)

Decreased

ERAS3.4%

-3,766,393(-27%)

URGN0.6%

-2,769,699(-62%)

SRRK1.2%

-1,836,077(-60%)

BBOT0.2%

-1,393,536(-62%)

ORIC0.4%

-700,000(-29%)

ABVX1.8%

-645,000(-46%)

EYPT0.8%

-549,038(-15%)

Exited

-1,500,000

-759,565

-2,210,774

-684,277

-2,935,284

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

Loading position changes...

Holdings

Loading holdings...